This hospital operates as part of the Metro TB Health Centre in the Southern-Western Sub-structure of the Metro District Health Services. The hospital offers in-patient services to clients with drug sensitive and multi-drug resistant (MDR) TB, on a referral basis. This hospital operates in the South Peninsula Health District of the Metro Region.

This hospital operates as part of the West Coast TB Complex in the West Coast District.

Nelspoort Hospital caters for both tuberculosis (TB) and mental health patients. The TB patients include multidrug-resistant TB (MDR) and extreme drug-resistant (XDR) patients. XDR patients are mostly from Brooklyn Chest Hospital and MDR patients from Harry Comay in George. Sensitive TB patients are from the Central Karoo. The Nelspoort Hospital, a 92-bed facility and is situated in Nelspoort, a small community several kilometres outside of Beaufort West.