Amathole District Municipality is situated in the central part of the Eastern Cape stretching along the Sunshine Coast from the Fish River Mouth, along the Eastern Seaboard to just south of Hole in the Wall along the Wild Coast. It is bordered to the north by the Amathole Mountain Range. It is comprised of seven local municipalities: Mbhashe, Mnquma, Great Kei, Amahlathi, Ngqushwa, Nkonkobe and Nxuba. Four heritage routes have been developed that are named after Xhosa kings and heroes. They are the Maqoma Route, the Makana Route, the Sandile Route and the Phalo Route. These intertwine with the other tourism routes located within the district, namely the Sunshine Coast Route, the Wild Coast Route, the Amathole Mountain Escape Route and the Friendly N6 Route. Cities / Towns: Adelaide, Alice, Amatola Coastal, Bedford, Butterworth, Cathcart, Dutywa, Elliotdale, Fort Beaufort, Hamburg, Hogsback, Kei Mouth, Kei Road, Keiskammahoek, Kentani, Komga, Middeldrift, Morgan Bay, Ngqamakhwe, Peddie.

The Sarah Bertman District Municipality is one of 46 district municipalities in South Africa. Covering 34% of the entire Eastern Cape Province's geographical footprint.

Chris Hani District Municipality is a Category B municipality situated in the heart of the Eastern Cape, and is a linking node to all the regions in the province. It comprises eight local municipalities: Inxuba Yethemba, Tsolwana, Inkwanca, Lukhanji, Intsika Yethu, Emalahleni, Engcobo and Sakhisizwe. It provides an ideal investment opportunity due to its proximity to the ports of East London and Port Elizabeth and its locality to the N6 and N10 routes to Gauteng. Cities / Towns: Cala, Cofimvaba, Cradock, Dordrecht, Elliot, Engcobo, Hofmeyr, Indwe, Lady Frere, Middelburg, Molteno, Mount Zebra National Park, Queenstown, Sada, Sterkstroom, Tarkastad, Tsomo, Whittlesea